Additionally, AOSLO imaging could play a role in monitoring the safety and efficacy of other therapeutic interventions aimed at restoring cone function and/or slowing cone degeneration. 1 The single-cell resolution afforded by AOSLO imaging provides information that is relevant for these gene therapy studies, as cones represent the cellular target for such therapeutic efforts. These results may be useful in guiding patient selection for AOSLO imaging.Translational relevanceUsing OCT to prescreen patients could be a valuable tool for clinical trials that utilize AOSLO to reduce costs and decrease patient testing burden.Ĭlinical trials and natural history studies for inherited retinal diseases such as achromatopsia (ACHM) are increasingly utilizing adaptive optics scanning light ophthalmoscopy (AOSLO) to assess cone structure. Subjects with less severe OCT artifacts are more likely to be good candidates for AOSLO imaging, whereas AOSLO was successful in only 7% of subjects with category 3 or 4 OCT artifacts. Neither BCVA nor axial length was associated with AOSLO success (P = 0.07 and P = 0.75, respectively).ConclusionsArtifacts in OCT volumes are associated with AOSLO success in ACHM.
There was a significant association between OCT artifact severity category and AOSLO success (P = 0.0002). For subjects with OCT artifact severity category 1, AOSLO success was 65% for category 2, 47% for category 3, 11% and for category 4, 0%. AOSLO success was defined as sufficient image quality in split-detector images at the fovea to assess cone quantity.ResultsThere was excellent agreement between the two observers for assessing OCT artifact severity category (weighted kappa = 0.88). Each vertical volume was assessed once by two observers. OCT artifacts in interpolated vertical volumes from CIRRUS macular cubes were divided into four categories: (1) none or minimal, (2) clear and low frequency, (3) low amplitude and high frequency, and (4) high amplitude and high frequency.
PurposeTo determine whether artifacts in optical coherence tomography (OCT) images are associated with the success or failure of adaptive optics scanning light ophthalmoscopy (AOSLO) imaging in subjects with achromatopsia (ACHM).MethodsPreviously acquired OCT and non-confocal, split-detector AOSLO images from one eye of 66 subjects with genetically confirmed achromatopsia (15 CNGA3 and 51 CNGB3) were reviewed along with best-corrected visual acuity (BCVA) and axial length.
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